目的:为调查本地区新生儿乙肝疫苗接种情况,观察免疫效果,及时为卫生部计划免疫策略提供可靠数据。方法:随机抽取本地7月~12月龄新生儿,采用调查表回顾调查新生儿出生情况、乙肝疫苗接种情况、父、母亲乙型肝炎病毒感染情况;采取调查对象静脉血3 ml,血清样品用美国雅培试剂测定乙肝表面抗体(HBsAb)滴度,定性测定表面抗原。结果:共调查2407例,其中3例为乙肝表面抗原阳性(阳性率0.147%),其余总有效率:抗体滴度大于10IU2323人,除去表面抗原阳性儿童,总应答率:96.63%。HBsAb滴度≥10 IU/ml及≥1000 IU/ml 7月~12月龄儿童分布情况,随月龄增加,差异均具有统计学意义。各月龄之间HBsAb滴度≥10 IU/ml者差异不明显,滴度≥1000 IU/ml者8月与9月龄、10月与11月龄之间差异有显著意义。结论:调查地区乙肝疫苗免疫效果显著,乙肝表面抗原阳性率低于全国0.96%水平;乙肝表面抗体滴度随着月龄增加,呈下降趋势;低滴度水平(<10 IU/ml)儿童仍占一定比例(3.37%),需及时加强免疫。 Objectives: To investigate the situation of hepatitis B vaccination in newborns in our region and observe the immune effect, provide reliable data for the planned immunization strategy of Ministry of Health in time. Methods: Local neonates from July to 12 months were randomly selected. The newborns’ birth, hepatitis B vaccination, and the infection of hepatitis B virus (HBV) of the mother and father were investigated by questionnaire. The blood samples Abbott reagent for the determination of hepatitis B surface antibody (HBsAb) titer, qualitative determination of surface antigen. Results: A total of 2407 cases were investigated, of which 3 were positive for HBsAg (positive rate 0.147%). The remaining total effective rate was 23231 with antibody titer greater than 10IU. The overall response rate was 96.63%. The distribution of children with HBsAb titer ≥10 IU / ml and ≥1000 IU / ml from July to 12 months were statistically significant with the increase of age. There was no significant difference between HBsAb titers ≥ 10 IU / ml in all months. The titer of ≥1000 IU / ml in August and 9 months was significantly different between October and November. Conclusion: The immunization efficacy of hepatitis B vaccine in the surveyed areas was significant, and the positive rate of HBsAg was lower than 0.96% in China. The antibody titer of hepatitis B surface decreased with the increase of age. Children with low titer (<10 IU / ml) Accounting for a certain percentage (3.37%), need to be promptly strengthened immunity.