在全球范围内,胃癌居恶性肿瘤的第4位,病死率居恶性肿瘤的第2位[1]。据统计,全球每年新发胃癌93.4万例,且每年约有70万人死于胃癌,其中三分之二的新增病例出现在发展中国家(中国占42%)[2]。在中国,胃癌的发生率与病死率均居恶性肿瘤之首[3]。胃癌的预后很差,5年生存率不足20%。癌细胞侵袭转移是造成胃癌死亡的主要原因[4]。因此,探索胃癌浸润、转移的机制 Globally, gastric cancer ranks fourth in malignant tumors, with the second most common malignancy in the world [1]. According to statistics, there are 934,000 newly diagnosed cases of gastric cancer in the world each year, and about 700,000 people die of gastric cancer each year. Two thirds of the new cases occur in developing countries (42% in China) [2]. In China, the incidence of gastric cancer and mortality are among the first malignant tumors [3]. The prognosis of gastric cancer is poor, 5-year survival rate of less than 20%. Cancer cell invasion and metastasis is the main cause of gastric cancer death [4]. Therefore, to explore the mechanism of gastric cancer invasion and metastasis