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为观察异丙酚对应激反应的影响，随机选择颈丛阻滞麻醉下施行甲状腺瘤切除术患者25例，按术中辅助用药分为异丙酚组（n=11，1mg／kg）和对照组（n=14，氟哌啶0．1mg／kg+安定0．1mg／kg）。用放免法测定麻醉前、麻醉10min、处理甲状腺上极以及术毕皮质醇、血管紧张素Ⅱ和血清FT3，同时测定血压、心率和血糖。结果表明，异丙酚组皮质醇、血管紧张素Ⅱ均明显低于对照组。因此，该药能有效地抑制术中应激反应。
In order to observe the effect of propofol on stress response, 25 patients undergoing thyroidectomy under cervical plexus block anesthesia were randomly selected and divided into propofol group (n=11, 1 mg/kg) and control according to intraoperative adjuvant use. Group (n=14, haloperidol 0.1 mg/kg + diazepam 0.1 mg/kg). Radioimmunoassay was used to measure pre-anesthesia, anesthesia for 10 min, treatment of the thyroid upper pole, and operation of cortisol, angiotensin II, and serum FT3. Blood pressure, heart rate, and blood glucose were measured simultaneously. The results showed that the levels of cortisol and angiotensin II in the propofol group were significantly lower than those in the control group. Therefore, the drug can effectively inhibit the intraoperative stress response.