近年来,厌氧棒状杆菌菌苗在肿瘤免疫治疗中所起的作用,已渐引起许多学者的关注。本文通过临床治疗,观察了向食管癌、贲门癌患者瘤体局部注入国产CP所引起的超微结构的变化。菌苗治疗组与单纯手术组相比,癌细胞超微结构虽无明显变化,但治疗组癌细胞之间及其间质内的淋巴细胞均有显著增多。本文结合文献,对实验结果进行了讨论。 In recent years, the role of anaerobic coryneform bacterin in tumor immunotherapy has gradually attracted the attention of many scholars. This article through clinical treatment, observed the ultrastructural changes caused by local injection of domestic CP to esophageal or cardiac cancer patients. In the bacterin-treated group, there was no significant change in the ultrastructure of the cancer cells compared with the surgery alone group, but there was a significant increase in lymphocytes among the cancer cells and interstitial cells in the treated group. This article combines the literature and discusses the experimental results.