【摘 要】
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AIM: To evaluate the effect of pyrrolidine dithiocarbamate (PDTC; an NF-κB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing
【机 构】
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Department of Gastroenterology, Fujita Health University, Japan“,”Second Department of Internal Medi
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AIM: To evaluate the effect of pyrrolidine dithiocarbamate (PDTC; an NF-κB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis.METHODS: Mice were divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+PDTC-treated group Ⅰ (low-dose group), and DSS+PDTC-treated groupⅡ (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue were measured.RESULTS: The DSS+PDTC-treated group Ⅱ exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-kB level and IL-1β and TNF-α levels were significantly lower in DSS+PDTC-treated group Ⅱ.CONCLUSION: These findings suggest that PDTC is useful for the treatment of ulcerative colitis.
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