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自发性高血压大鼠(SHR)是1963年Okamoto用Wistar大鼠培育而成的,其被毛呈白色。此鼠高血压发生率高,在16周龄时高血压已形成,收缩压21.28kPa,无明显原发性肾脏或肾上腺损伤,心血管疾病发生率高。SHR从发病机制、高血压心血管并发症、外周血管阻力变化、对盐的敏感性等多方面来
Spontaneous hypertensive rats (SHRs) were cultured in 1963 in Okamoto with Wistar rats and their coat was white. The incidence of high blood pressure in rats, high blood pressure at 16 weeks of age has been formed, systolic blood pressure 21.28kPa, no significant primary renal or adrenal damage, high incidence of cardiovascular disease. SHR from the pathogenesis, cardiovascular complications of hypertension, changes in peripheral vascular resistance, salt sensitivity and other aspects