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目的 探讨Ａｌｚｈｅｉｍｅｒ 病（ＡＤ） 患者脑脊液（ＣＳＦ） 中细胞凋亡因子Ｆａｓ 抗原含量变化的临床意义。方法 采用ＥＬＩＳＡ方法测定了２７ 例ＡＤ、１２ 例多发梗死性痴呆（ＭＩＤ） 和对照组１７ 例患者ＣＳＦＦａｓ 抗原含量。结果 患者ＣＳＦ中Ｆａｓ 抗原含量为ＡＤ 组（１１－１１９ ±３－０９５） ｎｇ／ｍｌ，稍低于ＭＩＤ 组的（１２－６６０ ±７－８９３） ｎｇ／ｍｌ 及对照组的（１３－２７０±８－４９１） ｎｇ／ｍｌ，但三组间Ｆａｓ 含量的差异无统计学意义（Ｐ＞０－０５）；ＡＤ组中不同年龄段或不同痴呆程度患者的ＣＳＦＦａｓ 抗原水平的差异均无显著性（均为Ｐ＞ ０－０５） 。结论 ＣＳＦ中Ｆａｓ 抗原含量的变化对ＡＤ的诊断及鉴别诊断似无重要意义。
Objective To investigate the clinical significance of the changes of Fas antigen in cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD). Methods The contents of CSFFas antigen in 27 patients with AD, 12 patients with multi-infarct dementia (MID) and 17 controls were measured by ELISA. Results The level of Fas antigen in CSF was 11-119 ± 3-095 ng / ml in AD group, slightly lower than that in MID group (12-660 ± 7-893) ng / ml and in control group (13-270 ± 8-491) ng / ml, but there was no significant difference in the content of Fas between the three groups (P> 0-05). There was no significant difference in the level of CSFFas antigen among different age groups or dementia in AD group All P> 0-05). Conclusion The change of Fas antigen in CSF is of no significance for the diagnosis and differential diagnosis of AD.