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目的分析氨氯地平联合卡托普利治疗高血压合并冠心病(HCHD)临床疗效。方法选取郑州市第七人民医院2013年1月—2016年7月收治的74例高血压合并冠心病患者,采用随机数字表法分为观察组(37例)和对照组(37例),对照组给予常规综合治疗,观察组给予氨氯地平联合卡托普利治疗,治疗8周后统计比较两组总有效率,并对比两组血脂指标[低密度脂蛋白(LDL)、三酰甘油(TG)、高密度脂蛋白(HDL)、总胆固醇(TC)]水平。结果观察组总有效率97.30%(36/37)高于对照组75.68%(28/37),差异具有统计学意义(χ~2=7.400,P<0.05);治疗8周后观察组LDL、TG、TC低于对照组,HDL高于对照组,差异具有统计学意义(P<0.05)。结论高血压合并冠心病以氨氯地平联合卡托普利治疗,可减少心绞痛发作次数,改善患者血脂代谢,有效控制患者血压水平,疗效显著。
Objective To analyze the clinical efficacy of amlodipine combined with captopril in the treatment of hypertension complicated with coronary heart disease (HCHD). Methods Seventy-four patients with hypertension and coronary heart disease admitted from the Seventh People’s Hospital of Zhengzhou City from January 2013 to July 2016 were divided into observation group (37 cases) and control group (37 cases) by random number table. The patients in the observation group were treated with amlodipine combined with captopril. The total effective rate was compared between the two groups after 8 weeks of treatment. The levels of serum lipids, including low density lipoprotein (LDL) and triglyceride TG), high density lipoprotein (HDL) and total cholesterol (TC). Results The total effective rate in the observation group was 97.30% (36/37) higher than that in the control group (75.68%, 28/37), the difference was statistically significant (χ ~ 2 = 7.400, P < TG, TC lower than the control group, HDL higher than the control group, the difference was statistically significant (P <0.05). Conclusion High blood pressure combined with coronary heart disease with amlodipine combined with captopril treatment can reduce the number of angina attacks, improve blood lipid metabolism in patients with effective control of blood pressure in patients with significant effect.