以电化学和光谱电化学方法探讨了合成辅酶B12模型化合物的条件。在此基础上用化学方法合成了系列轴向基团具有纯电子效应的辅酶B12模型化合物RPhCH_2-CoTMAPI(R=CH_(3-),NO_(2-),H-,Br-,KCO_(2-),COTMAP I为碘化四[N,N,N-三甲胺基]苯基钴卟啉)。以红外,紫外可见光谱对它们进行了表征。用量子化学方法讨论电子效应对Co-C键的影响。 The conditions for the synthesis of coenzyme B12 model compounds were discussed by electrochemical and spectral electrochemical methods. On this basis, we synthesized a series of coenzyme B12 model compounds with pure electron effect, whose axial groups have the pure electron effect. The results showed that RPhCH 2 -CoTMAPI (R = CH 3 -, NO 2 -, H-, Br- and KCO 2 -), COTMAP I is tetrakis [N, N, N-trimethylamino] phenyl cobalt porphyrin). They were characterized by infrared and UV-Vis spectra. Quantum Chemical Method to Discuss the Effect of Electron Effect on Co-C Bond.