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背景:有学者认为在脑死亡过程中很多因素可导致肺组织的改变。目的:观察脑死亡供体肺病理改变,探讨其临床移植应用的可行性。方法:对23例脑死亡供体肺进行了病理活检,苏木精-伊红染色、银染及PAS染色观察肺脏组织变化,电镜观察肺脏超微结构变化。结果与结论:苏木精-伊红、银染及PAS染色光镜下见支气管及肺泡结构尚完整,局部病灶见肺泡内皮细胞水肿、坏死、脱落,肺泡间隔未见明显增宽,但充血易见,血管周围有少量出血,有散在淋巴细胞;电镜下脑死亡的肺泡细胞轻微水肿,部分细胞胞核染色质沿皱缩的核膜下凝聚,有的细胞核出现变型,细胞线粒体肿胀,但未见明显坏死。说明脑死亡供肺可以实施临床移植。
Background: Some scholars believe that many factors in the process of brain death can lead to lung tissue changes. Objective: To observe the pathological changes of donor lungs after brain death and to explore the feasibility of clinical transplantation. Methods: Pathological biopsy was performed on 23 cases of brain death donor lungs. The changes of lung tissues were observed by hematoxylin - eosin staining, silver staining and PAS staining. The ultrastructural changes of lung were observed by electron microscope. RESULTS AND CONCLUSION: Bronchial and alveolar structures were still intact under hematoxylin-eosin, silver staining and PAS staining. Edema, necrosis and exfoliation of alveolar endothelial cells were observed in local lesions. There was no obvious broadening of alveolar septum. See, a small amount of bleeding around the blood vessels, scattered lymphocytes; electron microscopy alveolar mild edema brain cells, some of the cells along the nuclear chromatin chromatin condensation, some nuclear variants, mitochondria swelling, but no see Obvious necrosis. Description of brain death for lung transplantation can be implemented.