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目的观察与评价甲巯咪唑联合普萘洛尔治疗甲状腺功能亢进症(甲亢)的临床疗效。方法 90例甲亢患者,按照治疗方法不同将其分为A组(46例)与B组(44例)。A组患者给予甲巯咪唑联合普萘洛尔治疗,B组患者给予甲巯咪唑治疗。比较两组疗效与甲状腺激素水平。结果 A组治疗总有效率为95.65%,B组为81.82%,A组治疗总有效率明显高于B组,差异有统计学意义(P<0.05)。治疗后,A组血清游离三碘甲腺原氨酸(FT_3)、游离甲状腺素(FT_4)水平分别为(17.24±1.97)、(7.42±1.06)pmol/L,明显低于B组的(22.34±2.22)、(20.61±2.53)pmol/L,差异均有统计学意义(P<0.05)。结论甲巯咪唑联合普萘洛尔治疗甲亢的临床疗效更为显著,能够使患者的血清甲状腺激素水平得到明显的降低,可在临床中普遍推广。
Objective To observe and evaluate the clinical efficacy of methimazole combined with propranolol in the treatment of hyperthyroidism (hyperthyroidism). Methods Ninety patients with hyperthyroidism were divided into group A (n = 46) and group B (n = 44) according to the different treatment methods. Patients in group A were treated with methimazole plus propranolol, and patients in group B were given methimazole. Efficacy and thyroid hormone levels were compared between the two groups. Results The total effective rate of group A was 95.65%, while that of group B was 81.82%. The total effective rate of group A was significantly higher than that of group B, the difference was statistically significant (P <0.05). After treatment, the levels of free triiodothyronine (FT_3) and free thyroxine (FT_4) in group A were (17.24 ± 1.97) and (7.42 ± 1.06) pmol / L respectively, which were significantly lower than those in group B ± 2.22) and (20.61 ± 2.53) pmol / L, respectively (all P <0.05). Conclusion The clinical efficacy of methimazole combined with propranolol in the treatment of hyperthyroidism is more significant, which can make patients’ serum thyroid hormone levels significantly reduced, which can be widely promoted in clinic.