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目的:探讨血清可溶性细胞间粘附分子-1(sICAM-1)在病毒相关性喘息性支气管炎发病中的作用,分析血清sICAM-1水平与喘息反复发作的高危因素者之间的关系。方法:采用酶联免疫吸附试验方法测定70例病毒相关性喘息性支气管炎急性期和恢复期以及30例健康儿童血清sICAM-1水平,分析病毒相关性喘息性支气管炎喘息反复发作的可能相关因素。结果:急性期血清sICAM-1水平高于恢复期和对照组,差异有统计学意义(P<0.05);恢复期血清sICAM-1水平与对照组比较差异无统计学意义(P>0.05)。随访期内有23例患儿喘息反复发作,其血清sICAM-1水平为(218.94±60.82)ng/ml。有过敏性疾病史和遗传史患儿血清sICAM-1水平显著高于无过敏性疾病史和遗传史患儿,差异有统计学意义(P<0.05)。结论:血清sICAM-1参与了病毒相关性喘息性支气管炎发生和发展以及喘息复发,有过敏性疾病和遗传史病毒感染所致的喘息性支气管炎患儿易喘息反复发作。
Objective: To investigate the role of serum soluble intercellular adhesion molecule-1 (sICAM-1) in the pathogenesis of virus-associated asthmatic bronchitis and to analyze the relationship between serum sICAM-1 level and risk factors of recurrent wheezing. Methods: Serum levels of sICAM-1 in 70 patients with viral-associated asthmatic bronchitis were determined by enzyme-linked immunosorbent assay (ELISA) and the possible correlates of recurrent wheezing with viral-associated asthmatic bronchitis . Results: The level of serum sICAM-1 in acute phase was higher than that in recovery phase and control group (P <0.05). The level of sICAM-1 in recovery phase was not significantly different from that in control group (P> 0.05). During the follow-up period, 23 children had wheezing recurrently and the serum sICAM-1 level was (218.94 ± 60.82) ng / ml. Children with allergic disease history and genetic history serum sICAM-1 levels were significantly higher than those without allergic disease history and genetic history, the difference was statistically significant (P <0.05). Conclusion: Serum sICAM-1 is involved in the occurrence and development of virus-associated asthmatic bronchitis and recurrent wheezing. Patients with asthmatic bronchitis caused by allergic diseases and genetic history virus recurrent asthma.