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目的观察单纯性肥胖儿童血浆瘦素及可溶性瘦素受体质量浓度的变化,探讨其相互之间及与体重指数(BMI)之间的关系。方法于2005-06北京儿童医院采用酶联免疫吸附试验(ELISA)对40例3~6岁的单纯性肥胖儿童及按性别、年龄1∶1配对的40例正常儿童进行了血浆瘦素及可溶性瘦素受体质量浓度的检测。结果肥胖儿童血浆瘦素质量浓度(22.26±2.30)μg/L较正常儿童(3.36±0.23)μg/L明显升高,可溶性瘦素受体质量浓度(100.10±24.60)μg/L较正常儿童(132.31±30.17)μg/L则明显降低(P<0.001)。相关性分析显示,瘦素与可溶性瘦素受体水平之间呈负相关;BMI与瘦素呈正相关,而与可溶性瘦素受体呈负相关(P<0.05)。结论学龄前肥胖儿童已存在明显的瘦素抵抗现象,而可溶性瘦素受体表达减少,可能参与了瘦素抵抗的发生。
Objective To observe the changes of plasma leptin and soluble leptin receptor in simple obesity children and explore their relationship with each other and body mass index (BMI). METHODS: Enzyme-linked immunosorbent assay (ELISA) was performed on 40 children with simple obesity aged 3 to 6 years and 40 normal children matched by sex and age 1: 1 in Beijing Children’s Hospital from 2005 to June 2005. Plasma leptin and soluble Detection of leptin receptor mass concentration. Results Compared with normal children (3.36 ± 0.23) μg / L, the levels of plasma leptin in obese children (22.26 ± 2.30) μg / L were significantly higher than those in normal children (100.10 ± 24.60) μg / L 132.31 ± 30.17) μg / L was significantly lower (P <0.001). Correlation analysis showed that there was a negative correlation between leptin and soluble leptin receptor. BMI was positively correlated with leptin but negatively correlated with soluble leptin receptor (P <0.05). Conclusion Leptin resistance exists in pre-school obese children, but the expression of soluble leptin receptor is decreased, which may be involved in the occurrence of leptin resistance.