目的探讨甲硝唑、替硝唑和奥硝唑3种硝基咪唑类药物治疗滴虫性阴道炎患者的临床疗效和不良反应情况。方法选取2014年3月至2015年7月在沈阳军区总医院确诊为滴虫性阴道炎的患者156例为研究对象,按随机数字表法分为甲硝唑组、替硝唑组、奥硝唑组,每组52例。3组患者分别口服甲硝唑、替硝唑、奥硝唑治疗,连续用药7 d后随访,比较3组患者的疗效和不良反应发生情况。结果奥硝唑组患者的治疗显效率和总有效率均高于替硝唑组和甲硝唑组,差异均有统计学意义(P<0.05);替硝唑组总有效率高于甲硝唑组,差异有统计学意义(P<0.05);奥硝唑组患者的不良反应发生率(7.7%)低于替硝唑组(13.5%)和甲硝唑组(19.2%),差异有统计学意义(P<0.05)。结论与替硝唑和甲硝唑相比,奥硝唑在治疗滴虫性阴道炎时具有更好的疗效和更低的不良反应发生率,是一种较为理想的治疗药物。 Objective To investigate the clinical efficacy and adverse reactions of three kinds of nitroimidazole metronidazole, tinidazole and ornidazole in the treatment of trichomonas vaginitis. Methods A total of 156 patients with trichomonas vaginitis diagnosed in General Hospital of Shenyang Military Command from March 2014 to July 2015 were selected as the research object and divided into metronidazole group, tinidazole group, Azole group, 52 cases in each group. Three groups of patients were treated with metronidazole, tinidazole and ornidazole, respectively. The patients were followed up for 7 days. The curative effect and adverse reactions of the three groups were compared. Results The effective rate and total effective rate of ornidazole group were significantly higher than that of tinidazole group and metronidazole group (P <0.05). The total effective rate of tinidazole group was higher than that of metronidazole (P <0.05). The incidence of adverse reactions in the ornidazole group was lower than that in the tinidazole group (13.5% vs metronidazole group, 7.7% vs Statistical significance (P <0.05). Conclusion Compared with tinidazole and metronidazole, ornidazole in the treatment of trichomonas vaginitis has a better effect and a lower incidence of adverse reactions, is an ideal therapeutic drug.