论文部分内容阅读
目的 探讨急性心肌梗死(AMI)病人的肌钙蛋白I(cTnI)的含量与梗死面积和部位的关系 ,以评估AMI的病情程度及预后。方法 健康对照组 60例 ,于 0 9:0 0空腹抽静脉血 3ml,分离血清。AMI组 5 8例 ,于胸痛发作后 3h、6h、9h、12h时抽静脉血 3ml,分离血清。cTnI采用化学发光免疫分析法 (CLIA)定量检测。肌酸激酶同工酶 (CK -MB)采用连续监测法定量检测。结果 急性广泛前壁梗死病人的cTnI含量与对照组及急性前壁、间壁梗死、急性下壁、侧壁梗死组比较有统计学意义 (P <0 .0 1) ,与急性非Q波性梗死组比较无统计学意义 (P >0 .0 5 )。cTnI含量与CK -MB有良好的相关性。结论 用CK -MB计算梗死面积已得到病理和临床证实。cTnI含量与CK -MB有良好的相关性 ,说明cTnI含量越高AMI病人的梗死面积越大。实验结果表明 ,cTnI含量与AMI病人的梗死面积呈正相关 ,与梗死部位无明显相关性。
Objective To investigate the relationship between the content of troponin I (cTnI) and infarction area and location in patients with acute myocardial infarction (AMI) to evaluate the severity and prognosis of AMI. Methods Sixty healthy control subjects were enrolled in this study. Serum was collected from 3 ml fasting venous blood at 0 9: 0 0. In the AMI group, 58 cases were given 3 ml venous blood 3h, 6h, 9h, 12h after the onset of chest pain, serum was separated. cTnI using chemiluminescence immunoassay (CLIA) quantitative detection. Creatine kinase isoenzyme (CK-MB) using continuous monitoring quantitative detection. Results The cTnI level in patients with acute extensive anterior wall infarction was significantly higher than that in the control group and the acute anterior wall, septal infarction, acute inferior wall and lateral wall infarction group (P <0.01), and acute non-Q wave infarction Group had no statistical significance (P> 0.05). cTnI content and CK-MB have a good correlation. Conclusion The infarction area calculated by CK-MB has been confirmed by pathology and clinic. cTnI content and CK-MB have a good correlation, indicating that the higher the cTnI content AMI patients infarct area. The experimental results show that, cTnI content and AMI patients with infarction area was positively correlated, and no significant correlation with infarction.