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目的：对比头孢他啶（复达欣）、头孢曲松（罗氏芬）鞘内注射治疗脑室外引流术后颅内感染的效果。方法将58例脑室外引流术后颅内感染患者随机分为复达欣组和罗氏芬组各29例。复达欣组给予复达欣鞘内注射，罗氏芬组给予罗氏芬鞘内注射，治疗后比较2组临床疗效。结果复达欣组总有效率为96．6％，罗氏芬组总有效率为93．1％，2组总有效率比较差异无统计学意义（P＞0．05）。结论复达欣和罗氏芬作为目前临床常用的鞘内或脑室内注射药物，疗效显著，值得在临床推广应用。“,”Objective To compared the clinical effect of ceftazidime and ceftriaxone intrathecal injection in intracra -nial infection after ventricular drainage surgery .Methods 58 cases patients with intracranial infection after ventricular drain-age surgery were randomly divided into ceftazidime group and ceftriaxone sodium group ,each of 29 cases.Ceftazidime group in-trathecal injection with ceftazidime 100mg,ceftriaxone sodium group intrathecal injection with ceftriaxone sodium 100mg.After treatment,compared the clinical effect of 2 groups.Results The total efficiency of ceftazidime group was 96.6%,The total ef-ficiency of ceftriaxone sodium group was 93.1%,The total efficiency of 2 groups was no statistically significant (P>0.05). Conclusion Ceftazidime and ceftriaxone sodium as commonly used in clinical intraventricular or intrathecal injection of drugs,and the curative effect is significant , which is worthy to be popularized and applied in clinical .