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目的观察心律失常患者QT离散度(QTd)变化及索他洛尔对其影响。方法40例30~68岁的室性心律失常患者接受索他洛尔治疗,剂量从80mg/d开始,观察2周,若疗效未达标准者,增加到120mg/d,以后根据病情变化逐渐减量。结果40例室性心律失常患者应用索他洛尔治疗有效,并发现该药在应用后延长Q-Tc(QT间期)同时,减小QT离散度,未见严重毒副作用。结论索他洛尔治疗室性心律失常,安全有效,能影响患者QT离散度,减少室性心律失常的复发及室颤发生。
Objective To observe the changes of QTd in patients with arrhythmia and the effects of sotalol on it. Methods Forty patients with ventricular arrhythmias aged 30-68 years were treated with sotalol. The dosage started from 80mg / day for 2 weeks. If the effect was not reached to 120mg / d, the patients were gradually reduced according to the condition the amount. Results 40 patients with ventricular arrhythmia were treated with sotalol, and found that the drug prolonged Q-Tc (QT interval) and reduced QT dispersion after application, with no serious side effects. Conclusion Sotalol treatment of ventricular arrhythmias, safe and effective, can affect the patient QT dispersion, reduce the recurrence of ventricular arrhythmias and occurrence of ventricular fibrillation.