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目的探讨各种手术对胆囊癌预后的影响。方法 60例胆囊癌患者病变早期组5例,行单纯胆囊切除术;晚期组55例,行探查活检术24例、姑息切除术26例、根治性切除术5例。结果早、晚期组1、3、5年生存率分别为100%(5/5)、60%(3/5)、20%(1/5)和18.2%(10/55)、5.5%(3/55)、1.8%(1/55)(1年 P<0.001、3年 P<0.01、5年 P>0.05),晚期组探查活检术者均在1年内死亡;姑息性切除术者1年生存率23.1%(6/26),无3年、5年生存;根治性切除术者1、3、5年生存率分别为80%(4/5)、60%(3/5)、20%(1/5)(1年 P<0.001、3年 P<0.001、5年 P<0.01)。结论早期发现和根治性手术是提高胆囊癌患者生存率的有效方法。
Objective To explore the effect of various operations on the prognosis of gallbladder carcinoma. Methods 60 patients with gallbladder carcinoma were treated with simple cholecystectomy in 5 cases in the early stage of the disease, 55 cases in the late stage, 24 cases were examined biopsy, 26 cases were palliative resection, and 5 cases were radical resection. Results The 1-, 3-, and 5-year survival rates of the early and late groups were 100% (5/5), 60% (3/5), 20% (1/5), and 18.2% (10/55), 5.5% ( 3/55), 1.8% (1/55) (P<0.001 for 1 year, P<0.01 for 3 years, P>0.05 for 5 years). All patients in late-stage group biopsy died within 1 year; Palliative resection 1 The annual survival rate was 23.1% (6/26), with no survival of 3 years and 5 years. The 1-, 3-, and 5-year survival rates of radical resection were 80% (4/5), 60% (3/5), respectively. 20% (1/5) (P<0.001 for 1 year, P<0.001 for 3 years, P<0.01 for 5 years). Conclusion Early detection and radical surgery are effective methods to improve the survival rate of gallbladder cancer patients.