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目的:对药物三联法在妊娠高血压患者疾病治疗中的作用效果以及对患者血清LIF、Apelin水平变化的影响进行研究分析。方法:选取我院收治的140例妊娠高血压疾病患者,将所有患者随机分为观察组和对照组两个组别,每组各70例,临床中对观察组患者采用硫酸镁、拉贝洛尔和尼莫地平三种药物联合治疗,对照组患者仅采用硫酸镁治疗,观察对比两组患者的治疗效果与血清LIF、Apelin水平变化。结果:观察组患者治疗有效率为97.1%,对照组患者为81.4%,两组对比差异突出,P<0.05;此外,治疗结束后,观察组患者血清LIF、Apelin水平与对照组两组存在较为突出的差异(P<0.05),与正常体检者相比,差异无统计学意义(P>0.05),而对照组患者与正常体检者血清LIF、Apelin水平差异具有统计学意义(P<0.05)。结论:三种药物联合形式进行妊娠高血压患者治疗应用,具有较好的作用效果,值得临床推广应用。
OBJECTIVE: To study the effects of triple therapy in the treatment of diseases of pregnancy-induced hypertension and the changes of serum LIF and Apelin levels. Methods: 140 cases of pregnancy-induced hypertension in our hospital were selected, all patients were randomly divided into observation group and control group two groups, 70 cases in each group, clinical observation group patients with magnesium sulfate, And nimodipine three drugs in combination, the control group of patients treated with magnesium sulfate, the treatment was observed in two groups compared with the treatment of serum LIF, Apelin levels. Results: The effective rate of treatment group was 97.1% in the observation group and 81.4% in the control group, with significant difference between the two groups (P <0.05). In addition, after the treatment, serum LIF and Apelin levels in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference between the two groups (P> 0.05), but there was no significant difference between normal subjects and control subjects (P> 0.05) . Conclusion: The combination of three drugs for the treatment of patients with pregnancy-induced hypertension has a good effect, it is worthy of clinical application.