【摘 要】
：
The Chinese compound Kaixin Jieyu Fang can be used to treat vascular depression;however, the underlying mechanism remains unclear. This study established a rat
【机 构】
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Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
论文部分内容阅读
The Chinese compound Kaixin Jieyu Fang can be used to treat vascular depression;however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin Jieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere-bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.
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