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目的对血清胱抑素C在IgA肾病中肾小球滤过功能的效果评价分析。方法资料随机选择2011年1月~2013年1月在本院诊治的IgA肾病患者120例,按照患者的临床类型分成四组,每组30例,肾病综合征患者为A组,血尿患者为B组,慢性肾炎患者为C组,急性肾炎患者作为D组,同期的健康体检30例作为对照组。对五组的血清胱抑素C、血清肌酐(SCr)浓度和内生肌酐的清除率等进行分析。结果经检测发现,A组和B组患者的SCr和Ccr,与对照组无明显差异(P>0.05);各组IgA肾病患者的CysC浓度,均高于对照组,差异明显,具有统计学意义(P<0.05);A组、B组和C组的血清胱抑素C异常率,均高于血清肌酐异常率,差异明显,具有统计学意义(P<0.05);IgA肾病中的血清胱抑素C和内生肌酐的清除率检测分析,两者呈现高度的负相关性(P<0.05)。结论对于IgA肾病患者的相关检查中,血清胱抑素C的浓度检测变化效果更为明显,便于更早期的进行肾功能的损害检查,临床应用上具有重要价值。
Objective To evaluate the effect of serum cystatin C on glomerular filtration function in IgA nephropathy. Methods Data were randomly selected 120 cases of IgA nephropathy diagnosed and treated in our hospital from January 2011 to January 2013, divided into four groups according to the clinical type of the patients, 30 cases in each group, group A with nephrotic syndrome, group B with hematuria Group, patients with chronic nephritis as C group, patients with acute nephritis as Group D, the same period, 30 cases of healthy physical examination as a control group. Five groups of serum cystatin C, serum creatinine (SCr) concentration and endogenous creatinine clearance rate were analyzed. Results The levels of SCr and Ccr in group A and group B were not significantly different from those in control group (P> 0.05). The levels of CysC in patients with IgA nephropathy in each group were significantly higher than those in control group (P <0.05). The abnormalities of serum cystatin C in group A, group B and group C were all higher than those of serum creatinine, with significant difference (P <0.05). Serum cyst in IgA nephropathy The clearance rate of endostatin C and endogenous creatinine showed a highly negative correlation (P <0.05). Conclusions In the correlation examination of patients with IgA nephropathy, the detection effect of serum cystatin C concentration is more obvious, which is convenient for the earlier examination of renal function damage and has clinical value.