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目的:探讨早期应用纳洛酮治疗慢性呼吸衰竭合并肺性脑病患者的临床效果。方法:选取慢性呼吸衰竭合并肺性脑病患者110例,随机将样本分为对照组与观察组各55例。对照组患者开展给予吸氧、纠正酸碱平衡与电解质紊乱联合抗生素药物的临床治疗,观察组患者在对照组的基础上增加纳洛酮药物治疗。结果:经临床治疗后,两组患者的PaO2均有显著上升,且PaCO2有显著的下降,治疗前后差异具有统计学意义(P<0.05),两组间治疗前后比较,差异无统计学意义(P>0.05)。两组患者经的临床症状与体征均改善时间比较,观察组显著好于对照组,具有统计学意义(P<0.05)。对照组治愈有效44例,总有效率为80.0%,观察组治愈有效51例,总有效率为92.7%,组间差异显著具有统计学意义(P<0.05),提示观察组患者的临床效果更好。结论:早期应用纳洛酮治疗慢性呼吸衰竭合并肺性脑病患者,能够有效改善患者的呼吸衰竭与精神受损情况,具有确切的临床效果。
Objective: To investigate the clinical effect of early application of naloxone in patients with chronic respiratory failure and pulmonary encephalopathy. Methods: A total of 110 patients with chronic respiratory failure and pulmonary encephalopathy were selected and randomly divided into control group and observation group (n = 55). Patients in the control group were given the clinical treatment of oxygen inhalation, correction of acid-base balance and electrolyte imbalance combined with antibiotics. The patients in the observation group were treated with naloxone on the basis of the control group. Results: After treatment, PaO2 in both groups increased significantly and PaCO2 decreased significantly (P <0.05). There was no significant difference between the two groups before and after treatment (P <0.05) P> 0.05). The clinical symptoms and signs of both groups were improved compared with the time, the observation group was significantly better than the control group, with statistical significance (P <0.05). The control group was cured and effective in 44 cases, the total effective rate was 80.0%. The observation group was cured and effective in 51 cases, the total effective rate was 92.7%, the difference between groups was statistically significant (P <0.05), suggesting that the observation group patients clinical effect more it is good. Conclusion: The early application of naloxone in patients with chronic respiratory failure and pulmonary encephalopathy can effectively improve the patient’s respiratory failure and mental deterioration, with a definite clinical effect.