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产前检测Ｒｈ，Ｄ因子及抗人球蛋白（ｃｏｏｍｂｓ）试验是必要的。测定Ｒｈ，Ｄ因子及抗Ｄ滴度使用木瓜酶方法。通过对１１２６１例孕妇常规检查Ｒｈ，Ｄ因子，发现Ｄ阴性７４例。Ｒｈ，Ｄ阴性妇女占６．５‰。２２例Ｒｈ，Ｄ阴性的孕妇所分娩的新生儿均为Ｒｈ，Ｄ阳性。其中２例孕妇血清抗Ｄ滴度为１∶３２，病情严重，宫内输血无效，胎死宫内。初产妇１３例，占５９％。活产２０例，存活率９０％。Ｒｈ因子及抗人球蛋白试验方法简便、易行，一般医院均可进行。对有流产史、输血史的孕妇检查Ｒｈ因子是十分必要的。在有条件的医院，对Ｒｈ，Ｄ阴性的产妇分娩Ｒｈ，Ｄ阳性的新生儿之后，产妇应预防性注射抗Ｄ免疫球蛋白
Prenatal testing of Rh, D factor and anti-human coombs (coombs) test is necessary. Determination of Rh, D factor and anti-D titers using papain method. By routine examination of 11261 pregnant women Rh, D factor, found that D-negative in 74 cases. Rh, D-negative women accounted for 6.5 ‰. Twenty-two Rh-positive and D-negative pregnant women were Rh-positive and D-positive. Two cases of pregnant women serum anti-D titer 1:32, a serious condition, intrauterine transfusion invalid, fetal death in the uterus. 13 cases of primipara, accounting for 59%. Live birth in 20 cases, the survival rate of 90%. Rh factor and anti-human globulin test method is simple, easy, the general hospital can be carried out. For abortion history, blood tests of pregnant women check Rh factor is very necessary. In a conditional hospital, maternal anti-D immunoglobulin should be given prophylactically after delivery Rh, D-negative mothers Rh, D-positive newborns