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目的探析妊娠滋养细胞疾病中血管内皮钙黏蛋白的表达及其临床意义。方法选取2010年12月至2015年4月在新疆医科大学第一附属医院就诊的50例妊娠滋养细胞疾病患者和20例行人工流产手术的正常早孕者作为本次研究的对象。其中,将妊娠滋养细胞疾病患者按照疾病类型分为A组、B组、C组以及D组,将正常早孕者作为本次研究的E组。结果 E组与A组的差异无统计学意义(P>0.05)。E组VE-cadherin m RNA的表达量均明显高于B组、C组以及D组,A组VE-cadherin m RNA的表达量均明显高于B组、C组以及D组,B组VE-cadherin m RNA的表达量均明显高于C组和D组,C组VE-cadherin m RNA的表达量明显高于D组;且差异均具有统计学意义(P<0.05)。结论 VE-cadherin m RNA的表达量与葡萄胎有着非常密切的关系,其下调与葡萄胎的恶变有着直接的关系;由此可知VE-cadherin m RNA的表达可成为检测妊娠滋养细胞疾病的参考指标,有着重大的临床意义。
Objective To investigate the expression of vascular endothelial cadherin in gestational trophoblastic disease and its clinical significance. Methods From December 2010 to April 2015, 50 cases of gestational trophoblastic disease and 20 normal pregnant women who underwent induced abortion were selected as the study objects in the First Affiliated Hospital of Xinjiang Medical University. Among them, the patients with gestational trophoblastic disease were divided into group A, group B, group C and group D according to the type of disease, and normal pregnant women were used as group E of this study. Results There was no significant difference between group E and group A (P> 0.05). The expression of VE-cadherin m RNA in group E was significantly higher than that in group B, C and D. The expression of VE-cadherin m RNA in group A was significantly higher than that in group B, group C, group D and group B, cadherin m RNA expression was significantly higher than those in group C and group D. The expression of VE-cadherin m RNA in group C was significantly higher than that in group D (P <0.05). Conclusions The expression level of VE-cadherin m RNA is closely related to hydatidiform mole. The down-regulation of VE-cadherin m RNA is directly related to the malignant transformation of hydatidiform mole. Therefore, the expression of VE-cadherin m RNA can be used as a reference index to detect gestational trophoblastic disease , Has great clinical significance.