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【目的】检测MAGE 3基因编码的抗原在非小细胞肺癌表达的情况 ,探讨利用MAGE 3抗原对非小细胞肺癌患者进行特异性免疫治疗的可能性。【方法】用免疫组化LSAB的方法对石蜡包埋的组织切片进行MAGE抗原的检测。【结果】 10 4例非小细胞肺癌原发灶肿瘤组织切片中 ,MAGE 3抗原阳性的有 31例 ,阳性率 2 9 8%。【结论】有相当部分非小细胞肺癌患者的肿瘤表达MAGE 3抗原 ,这些患者可能是进行MAGE 3基因编码的抗原介导的免疫治疗的合适人选。
【Objective】 To detect the expression of MAGE 3 gene in non-small cell lung cancer (NSCLC) and to explore the possibility of using MAGE 3 antigen for specific immunotherapy in patients with non-small cell lung cancer. 【Methods】 Paraffin-embedded tissue sections were examined for MAGE antigen using immunohistochemical LSAB method. 【Results】 Totally 31 cases of MAGE 3 antigen were positive in 104 primary non-small cell lung cancer tumor samples, the positive rate was 29.8%. [Conclusions] MAGE 3 antigens are expressed in a significant proportion of non-small cell lung cancer patients, and these patients may be suitable candidates for antigen-mediated immunotherapy encoded by the MAGE 3 gene.