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子痫前期是妊娠期特有的疾病,其病因及发病机制不清,大多数学者认为可能与某些遗传因素引发的免疫功能失调,造成滋养细胞侵润障碍,导致胎盘浅着床有关[1]。杀伤细胞免疫球蛋白样受体(KIR2DL4)通过识别滋养细胞表面的人类白细胞抗原G(HLA-G),向自然杀伤(NK)细胞传递抑制性信号,抑制NK细胞对胎儿成分的杀伤作用,其表达异常可能使胎儿和母体之间的免疫平衡失调,引发病
Preeclampsia is a unique disease during pregnancy, its etiology and pathogenesis is unclear, most scholars believe that some genetic factors may lead to immune dysfunction, resulting in trophoblast cell infiltration, resulting in placental shallow implantation [1] . Killer cell immunoglobulin-like receptor (KIR2DL4) inhibits natural killer (NK) cells by recognizing human leukocyte antigen G (HLA-G) on the surface of trophoblastic cells and inhibiting NK cell killing of fetal components. Abnormal expression may make immune balance between the fetus and maternal disorders, triggering the disease