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目的观察缬沙坦联合黄芪注射液治疗早期糖尿病肾病的临床效果与安全性。方法选择于2010年5月～2012年5月在我院治疗的早期糖尿病患者56例,随机分为治疗组与对照组,两组患者在入院后均给予胰岛素控制血糖,对照组26例,采用传统降压降糖治疗,并给予缬沙坦,80mg/d;治疗组30例,在对照组的基础上加用40ml黄芪注射液,加入250ml生理盐水静脉滴注,每日一次,持续30d,两组患者均于入院后第二天和治疗后检测空腹血糖、24h尿蛋白定量、血肌酐、尿素氮、糖化血红蛋白。结果治疗结束后,两组患者的腹血糖、24h尿蛋白定量、血肌酐、尿素氮、糖化血红蛋白指标均有所好转,但治疗组改善情况明显好于对照组,且组间差异具统计学意义,在治疗效果方面,治疗组显效21例,有效6例,无效3例,总有效率90%(27/30),对照组显效11例,有效8,无效7例,总有效率为73.0%(19/26),组间差异具统计学意义。结论缬沙坦联合黄芪注射液治疗早期糖尿病肾病临床效果良好,值得推广。
Objective To observe the clinical efficacy and safety of valsartan combined with astragalus injection in the treatment of early diabetic nephropathy. Methods Fifty-six patients with early-stage diabetes mellitus treated in our hospital from May 2010 to May 2012 were randomly divided into treatment group and control group. Both groups were given insulin-controlled blood glucose after admission. The control group received 26 Traditional antihypertensive therapy, and given valsartan, 80mg / d; treatment group 30 cases, on the basis of the control group plus 40ml astragalus injection, add 250ml normal saline intravenously once daily for 30d, Fasting blood glucose, 24h urinary protein, serum creatinine, urea nitrogen and glycosylated hemoglobin were detected in the two groups on the second day after admission and after treatment. Results After treatment, the indexes of blood glucose, 24h urinary protein, serum creatinine, urea nitrogen and glycosylated hemoglobin were improved in both groups, but the improvement in the treatment group was obviously better than that in the control group, and the difference between the two groups was statistically significant , In the treatment effect, the treatment group markedly effective in 21 cases, effective in 6 cases, invalid in 3 cases, the total effective rate was 90% (27/30), the control group markedly effective in 11 cases, effective 8, 7 cases, the total effective rate was 73.0% (19/26), the difference between groups was statistically significant. Conclusion Valsartan combined with Astragalus injection in the treatment of early diabetic nephropathy clinical effect is good, it is worth promoting.