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目的:研究芪红脑苏汤活血化瘀作用对局灶性脑缺血再灌注损伤大鼠的脑保护作用,并探讨其作用机制。方法:以线栓法复制局灶性脑缺血再灌注损伤大鼠模型,观察芪红脑苏汤对局灶性脑缺血再灌注损伤大鼠脑组织病理形态改变及脑组织中TNF-α、ICAM-1含量的影响。结果:与模型组比较,芪红脑苏汤31.4g/kg、15.7g/kg、7.9g/kg剂量组均能降低大鼠神经功能缺失评分及其病理评分分值;芪红脑苏汤31.4g/kg剂量组能降低缺血部位TNF-α表达,31.4g/kg、15.7g/kg剂量组能降低缺血部位ICAM-1的表达;芪红脑苏汤31.4g/kg、15.7g/kg、7.9g/kg剂量组均能降低缺血部位TNF-α含量,15.7g/kg、7.9g/kg剂量组能降低缺血部位ICAM-1的含量。结论:芪红脑苏汤的活血化瘀作用对局灶性脑缺血再灌注大鼠的脑损伤具有较好的保护作用,其作用机制可能与降低脑内TNF-α、ICAM-1含量有关。
Objective: To study the protective effect of Qi-ernao-soup on brain function in rats with focal cerebral ischemia-reperfusion injury and its mechanism. Methods: The rat model of focal cerebral ischemia / reperfusion injury was established by thread occlusion. The pathological changes of brain tissue in rats with focal cerebral ischemia-reperfusion injury were observed by using Qihongnaosu Decoction and the level of TNF-α , ICAM-1 content. Results: Compared with the model group, Qihongnao Soup 31.4g / kg, 15.7g / kg, 7.9g / kg dose group can reduce the neurological deficit score and pathological score score; g / kg dose group can reduce the expression of TNF-α in the ischemic area, 31.4g / kg, 15.7g / kg dose group can reduce the expression of ICAM-1 in ischemic area; Qihongnao soup 31.4g / kg, 7.9g / kg dose group can reduce the TNF-α content in the ischemic area, 15.7g / kg, 7.9g / kg dose group can reduce the content of ICAM-1 in ischemic area. CONCLUSION: QiHongNaSuTang’s blood-activating and removing blood-stasis function has a good protective effect on brain injury after focal cerebral ischemia-reperfusion in rats. The mechanism may be related to decreasing the content of TNF-α and ICAM-1 in the brain .