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为探讨阿法Ｄ３补肾健骨胶囊联合用药对实验性大鼠骨质疏松的预防作用，选用Ｗｉｓｔａｒ大鼠５０只，随机分５组，即正常对照组、模型组（骨质疏松）、阿法Ｄ３组、补肾健骨胶囊组和联合用药组（阿法Ｄ３＋补肾健骨胶囊）。除正常组外，其它４组均在给予相应药物同时，给维甲酸口服连续８天（模型组不给其它药）。８周后，结果显示：阿法Ｄ３和补肾中药组都有效的提高了维甲酸作用下的大鼠骨密度、骨强度；扫描电镜下，骨小梁排列规则，骨小梁断裂少，小梁密集。联合用药组骨密度、骨强度和电镜骨超微结构略优于阿法Ｄ３组和补肾中药组。提示：阿法Ｄ３和补健骨胶囊在一定程度上均可预防大鼠骨质疏松；联合用药对预防大鼠骨质疏松效果更好
In order to investigate the preventive effect of combined use of D3 and Shenzhejianjiao capsule on osteoporosis in experimental rats, 50 Wistar rats were randomly divided into 5 groups: normal control group, model group (osteoporosis) D3 group, Bushenjiangyu capsule group and combination group (Alfa D3 + Bushenjiangyu capsule). In addition to the normal group, the other four groups were given the corresponding drugs at the same time, oral retinoic acid for 8 consecutive days (the model group does not give other drugs). After 8 weeks, the results showed that: Alfa D3 and Bushen Chinese medicine group were effective in increasing the rat bone mineral density and bone strength under the action of retinoic acid; under the scanning electron microscope, trabecular arrangement, less trabecular broken, trabecular Intensive. The bone mineral density, bone strength and ultrastructure of the electron microscopy in the combination group were slightly better than those in the Alfa D3 group and Bushen Chinese medicine group. Tip: Alfa D3 and Bujian Capsule to a certain extent, can prevent osteoporosis in rats; combination of drugs to prevent osteoporosis better