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目的探讨不良妊娠史与染色体异常之间的关系,为临床提供指导意见。方法对117例不良妊娠史遗传咨询病例进行外周血淋巴细胞染色体核型分析。结果发现染色体异常核型13例,异常核型发生率为11.11%,其中,84例女性遗传咨询者中异常核型为7例,异常率为8.33%,33例男性遗传咨询者中异常核型6例,异常率为18.18%,男性染色体异常率高于女性。结论不良妊娠史与染色体核型异常有关,因此对有不良妊娠史的夫妇双方都进行染色体核型分析是十分必要的。对于染色体核型异常者下次妊娠必须进行宫内诊断,防止染色体病患儿的出生,提高出生人口素质。
Objective To investigate the relationship between history of adverse pregnancy and chromosomal abnormalities and provide guidance for clinical practice. Methods 117 cases of adverse pregnancy history of genetic counseling cases of peripheral blood lymphocyte chromosome karyotype analysis. The results showed that there were 13 cases of chromosomal abnormalities and 11.11% of abnormal karyotypes.Among them, there were 7 abnormal karyotypes in 84 female genetic counselors, the abnormality rate was 8.33%, and the abnormal karyotypes in 33 male genetic counselors 6 cases, the abnormal rate was 18.18%, males had a higher rate of chromosomal abnormalities than females. Conclusions The history of adverse pregnancy is related to abnormality of karyotype. Therefore, it is necessary to analyze the karyotypes of both couples with bad pregnancy history. Chromosome karyotype abnormalities in the next pregnancy must be intrauterine diagnosis to prevent the birth of children with chromosomal disease, improve the quality of the birth population.