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目的 :观察不稳定型心绞痛血浆 P 选择素变化及变化在调脂干预对急性冠状动脉 (冠脉 )事件的冠脉粥样病变炎症反应的影响。方法 :用酶联免疫吸附法及硝酸还原酶比色法测定 30例健康对照组和 6 2例冠心病不稳定型心绞痛患者应用辛伐他汀治疗前后的血浆 P选择素、氧化修饰低密度脂蛋白 ( OX L DL )和血清一氧化氮 ( NO)水平。结果 :不稳定性心绞痛组血浆 P选择素、OX L DL水平较对照组明显增高 ,血清 NO水平明显减低 ;血浆 P选择素水平与血浆 OX L DL水平呈显著正相关 ,与血清 NO水平显著负相关 ;辛伐他汀治疗 6周后不稳定型心绞痛组血浆 P 选择素、OX L DL 水平明显降低 ,血清 NO水平明显回升。结论 :( 1)急性冠脉事件的确存在着冠脉粥样病变的炎症反应 ;( 2 )冠脉粥样病变炎症反应与脂质过氧化及内皮细胞功能失常共同参与了急性冠脉事件的发生发展过程 ;( 3)调脂干预可阻断冠脉粥样病变的炎症反应 ,阻止病程的进展
Objective: To observe the changes of plasma P-selectin in patients with unstable angina pectoris and its effect on the inflammatory response of coronary atherosclerosis after intervention of lipid-lowering intervention. Methods: Serum levels of P-selectin and oxidized low density lipoprotein (LDL-C) were determined by enzyme-linked immunosorbent assay and nitrate reductase assay before and after treatment with simvastatin in 30 healthy controls and 62 patients with unstable angina pectoris. (OX L DL) and serum nitric oxide (NO) levels. Results: The levels of plasma P-selectin and OX-L-DL in patients with unstable angina pectoris were significantly higher than those in the control group, while the serum NO levels were significantly lower. Plasma P-selectin level was positively correlated with plasma OXLDL level, but not significantly with serum NO level 6 weeks after simvastatin treatment, plasma P-selectin and OXL-DL levels in patients with unstable angina pectoris were significantly lower and serum NO levels rose significantly. Conclusions: (1) There is indeed an inflammatory reaction of coronary atherosclerotic lesions in acute coronary events. (2) Coronary atherosclerosis inflammatory reaction and lipid peroxidation and endothelial cell dysfunction are involved in the occurrence of acute coronary events Development process; (3) lipid-lowering intervention can block the inflammatory response of coronary atherosclerosis, prevent the progress of the disease