动脉粥样硬化是一种常见的病理改变,也是心肌梗塞、脑梗塞和脑血栓形成的主要原因,但病因和发病机理至今还未完全阐明。早在1911年,用胆固醇喂家兔获得实验性动脉粥样硬化以来,认为脂类物质代谢失调,特别是胆固醇代谢失调是动脉粥样硬化的一个重要因素。大量的临床和实验室材料表明,动脉粥样硬化的发生与高血压、动脉内皮损伤等许多因素有 Atherosclerosis is a common pathological changes, but also the main cause of myocardial infarction, cerebral infarction and cerebral thrombosis, but the etiology and pathogenesis has not yet been fully elucidated. As early as 1911, cholesterol was fed to rabbits to obtain experimental atherosclerosis, lipids metabolic disorders, especially cholesterol metabolism disorders is an important factor in atherosclerosis. A large number of clinical and laboratory materials show that the occurrence of atherosclerosis and hypertension, arterial endothelial injury and many other factors