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目的分析2011—2016年河南省脑膜炎球菌疫苗(MenV)预防接种不良反应的发生特征,评价MenV预防接种的安全性。方法通过中国免疫规划信息管理系统疑似预防接种异常反应信息管理系统收集2011—2016年河南省MenV预防接种不良反应个案基本资料,采用描述流行病学方法进行分析。结果 2011—2016年河南省共报告MenV预防接种不良反应4 304例,年均报告发病率为10.69/10万剂次。A群脑膜炎球菌多糖疫苗、A群C群脑膜炎球菌多糖疫苗、A群C群脑膜炎球菌多糖结合疫苗、ACYW135群脑膜炎球菌多糖疫苗预防接种不良反应报告发生率分别为15.03/10万剂次、5.60/10万剂次、18.62/10万剂次、11.57/10万剂次。4 304例不良反应中,一般反应4 168例,占96.84%,报告发生率为10.36/10万剂次;异常反应136例,占3.16%,报告发生率为0.34/10万剂次。男性2 376例,女性1 928例,男女性别比为1.23∶1;≤1岁3 057例,占71.03%。64.66%的MenV不良反应发生在接种第1剂次后,78.28%发生在接种后1 d内。结论河南省MenV预防接种安全性良好,不良反应以一般反应为主,今后需继续规范MenV接种,做好接种前检查及接种后留观,减少严重不良反应的发生。
Objective To analyze the incidence of MenV vaccination adverse reactions in Henan Province from 2011 to 2016 and evaluate the safety of MenV vaccination. Methods Through the information system of immunization program of China Immunization Program, the basic information of MenV vaccination adverse reactions in 2011-2016 in Henan Province was collected and analyzed by descriptive epidemiological method. Results A total of 4 304 cases of MenV vaccination adverse reactions were reported in Henan province from 2011 to 2016, with an average annual incidence of 10.69 / 100 000 doses. Group A meningococcal polysaccharide vaccine, group A group C meningococcal polysaccharide vaccine, group A group C meningococcal polysaccharide conjugate vaccine, ACYW135 group meningococcal polysaccharide vaccine vaccination adverse reactions reported rates were 15.03 / 10 million doses Times, 5.60 / 10 million doses, 18.62 / 10 million doses, 11.57 / 10 million doses. Of the 4 304 adverse reactions, 4 168 were typical reactions, accounting for 96.84%, with a reported incidence of 10.36 / 10 000 doses. 136 were abnormal reactions, accounting for 3.16%. The reported incidence was 0.34 per 100 000 doses. There were 2 376 males and 1 928 females, with a male / female ratio of 1.23:1; 3 057 cases ≤1, accounting for 71.03%. 64.66% of MenV adverse reactions occurred after the first dose of inoculation and 78.28% occurred within 1 day after inoculation. Conclusion The safety of MenV vaccination in Henan Province is good. The adverse reactions are mainly general reactions. MenV vaccination should be continued in the future. Pre-vaccination examination and observation after vaccination should be done to reduce serious adverse reactions.