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目的:分析2型糖尿病(T2DM)患者尿微量白蛋白排泄率(UAER)与肾小球滤过率(eGFR)的关系,并探讨相关的危险因素。方法:选取我院收治的2型糖尿病患者470例,根据UAER及eGFR的检查结果进行分组,收集患者的一般资料,研究UAER与e GFR的关系,并分析其相关危险因素。结果:不同UAER体质量、体表面积、BMI,DBP,SBP,高血压病程、TG,TC,血肌酐以及尿酸水平比较,差异有统计学意义(P<0.05)。不同e GFR年龄、体质量、糖尿病病程、体表面积、BMI、高血压的病程、HbA1c,HDL-C,血肌酐以及尿酸水平比较,差异有统计学意义(P<0.05)。大量清蛋白尿患者肾功能异常发生率最高,正常清蛋白尿患者肾功能异常发生率最低,差异有统计学意义(P<0.05)。eGFR≥90 mL·min~(-1)·1.73 m~(-2)患者正常、微量、大量清蛋白尿分别占82.08%、13.68%、4.25%,根据交叉检验分析,UAER与e GFR间有相关性(P<0.05)。Logistic回归分析结果显示,与UAER相关危险因素包括血肌酐、收缩压及体质指数,与e GFR相关危险因素包括年龄、体质量、血肌酐(P<0.05)。结论:UAER与e GFR间存在相关性,一并进行检测对早期诊断2型糖尿病肾损伤有利。而两者相关危险因素包括血肌酐、收缩压及体质指数。
Objective: To analyze the relationship between urinary albumin excretion (UAER) and glomerular filtration rate (eGFR) in type 2 diabetes mellitus (T2DM) and to explore the related risk factors. Methods: A total of 470 patients with type 2 diabetes mellitus admitted to our hospital were enrolled and divided into groups according to the results of UAER and eGFR. The general data of patients were collected. The relationship between UAER and eGFR was analyzed and the related risk factors were analyzed. Results: The body weight, body surface area, BMI, DBP, SBP, duration of hypertension, TG, TC, serum creatinine and uric acid in different UAER patients were significantly different (P <0.05). The differences of eGFR age, body weight, duration of diabetes, body surface area, BMI, duration of hypertension, HbA1c, HDL-C, serum creatinine and uric acid were statistically significant (P <0.05). A large number of albuminuria patients had the highest incidence of renal dysfunction, renal dysfunction in patients with normal albuminuria was the lowest, the difference was statistically significant (P <0.05). eGFR≥90 mL · min -1 and 1.73 m -2 were 82.08%, 13.68% and 4.25% respectively. According to the cross-test analysis, there was significant difference between UAER and e GFR Correlation (P <0.05). Logistic regression analysis showed that the risk factors associated with UAER included serum creatinine, systolic blood pressure and body mass index. The risk factors associated with e GFR included age, body mass and serum creatinine (P <0.05). Conclusion: There is a correlation between UAER and e GFR, and it is beneficial to diagnose type 2 diabetic nephropathy early. The two related risk factors include serum creatinine, systolic blood pressure and body mass index.