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目的 初步探讨急性脑梗死患者体液免疫的改变。方法 抽取35例急性脑梗死患者静脉血 ,采用流式细胞仪检测不同病程患者CD19+CD25- 和CD19+CD25+淋巴细胞百分比 ,其中8例患者作自身对照 ,并运用多元逐步回归法寻找影响CD19+CD25+淋巴细胞百分比的因素。结果 患者CD19+CD25+淋巴细胞百分比在出现症状8天内明显较8天之后高(0.62%±0.32%和0.39%±0.22% ,t=2.40,P=0.026),CD19+CD25- 细胞亦有一定的差别(16.88 %±8.13%和12.70 %±4.16% ,t=1.90,P=0.093) ;8例自身对照患者结果类似。仅有病程与CD19+CD25+淋巴细胞百分比呈负相关 (r= -0.51,P=0.002)。 结论 急性脑梗死患者体液免疫被激活
Objective To investigate the changes of humoral immunity in patients with acute cerebral infarction. Methods Thirty-five patients with acute cerebral infarction were enrolled in this study. The percentage of CD19 + CD25- and CD19 + CD25 + lymphocytes were measured by flow cytometry. Eight patients were self-controlled, Factors for the percentage of CD25 + lymphocytes. Results The percentage of CD19 + CD25 + lymphocytes in patients with CD19 + CD25 + cells was significantly higher after 8 days (0.62% ± 0.32% vs 0.39% ± 0.22%, t = 2.40, P = 0.026) (16.88% ± 8.13% and 12.70% ± 4.16%, t = 1.90, P = 0.093). The results of 8 patients with self-control were similar. Only course of disease was negatively correlated with the percentage of CD19 + CD25 + lymphocytes (r = -0.51, P = 0.002). Conclusion The humoral immunity is activated in patients with acute cerebral infarction