骨重建是由破骨细胞介导的骨吸收和成骨细胞介导的骨形成维持骨骼代谢平衡的持续过程。炎症是局部及全身性骨丢失最主要的原因,细胞因子可通过多种信号途径参与破骨细胞的形成与活化,并且影响成骨细胞的成熟和功能,是类风湿关节炎炎性骨丢失机制的中心环节。 Bone remodeling is a continuous process mediated by osteoclast-mediated bone resorption and osteoblast-mediated bone formation to maintain bone metabolism balance. Inflammation is the most important cause of local and systemic bone loss. Cytokines are involved in the formation and activation of osteoclasts through a variety of signaling pathways and affect the maturation and function of osteoblasts. They are the mechanisms of inflammatory bone loss in rheumatoid arthritis Central part.