我院自1987年4月至1991年6月,采用氟尿嘧啶(5-Fu)加甲氰咪胍(CMT)治疗急性出血坏死性胰腺炎12例,疗效满意。1 临床资料.12例中男7例,女5例。年龄12～57岁。全部有突发上腹剧痛、恶心、呕吐、腹胀伴有腹膜刺激征,术前腹穿及术中均有血性腹水,血尿淀粉酶增高。术后合并有中毒性休克或心、肺、肝、肾等重要脏器严重并发症5例,腹腔残余脓肿2例。治愈11例,死亡1例。2 治疗方法.4例在门诊抽出血性腹水,其淀粉酶增高,入院后即予投药。8例经手术证实为急性出血坏死性胰腺炎,术后给药。5-Fu250～500mg加入5％～10％葡萄糖液500ml内,每日静滴1次。CMT800～1200mg日分3～4次小壶内滴入。疗程5～8天。用药 Our hospital from April 1987 to June 1991, the use of fluorouracil (5-Fu) plus cimetidine (CMT) treatment of acute hemorrhagic necrotizing pancreatitis in 12 cases, the effect is satisfactory. 1 clinical data .12 cases of male 7 cases, female 5 cases. Aged 12 to 57 years old. All sudden abdominal pain, nausea, vomiting, abdominal distension accompanied by peritoneal irritation, preoperative abdominal perforation and intraoperative bloody ascites, hematuria, amylase increased. Postoperative combined with toxic shock or heart, lung, liver, kidney and other important organ serious complications in 5 cases, 2 cases of abdominal residual abscess. Eleven patients were cured and one died. 2 treatment .4 cases of bloody ascites in the clinic, the amylase increased, after admission to the administration. 8 cases of acute hemorrhagic necrotizing pancreatitis confirmed by surgery, postoperative administration. 5-Fu250 ~ 500mg added 5% to 10% glucose solution 500ml, intravenous infusion 1 times a day. CMT800 ~ 1200mg day 3 to 4 drops of small drops. Treatment of 5 to 8 days. Medication