Non-erosive and uncomplicated erosive reflux diseases:Difference in physiopathological and symptom p

来源 :World Journal of Gastrointestinal Pathophysiology | 被引量 : 0次 | 上传用户:mrchangmeng
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
AIM:To investigate differences in the physiopathological findings(manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease(NERD) and erosive reflux disease(ERD) found positive at 24 h pH monitoring. METHODS:For a total of 670 patients who underwent 24 h pH monitoring,esophageal manometry and upper endoscopy were retrospectively evaluated,assessing the reflux symptoms,manometric characteristics of the lower esophageal sphincter(LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms were also evaluated. For inclusion in the study,patients had to have NERD or ERD and be found positive on pH monitoring(NERD+) . Patients with Gastroesophageal reflux disease(GERD) complicated by stenosis,ulcers or Barrett’s esophagus were ruled out. RESULTS:214 patients were involved in the study,i.e. 107 cases of NERD+ and 107 of ERD. There were no significant gender-or age-related differences between the two groups. The ERD group had more cases of hiatal hernia(P = 0.02) and more acid reflux,both in terms of number of reflux episodes(P = 0.01) and as a percentage of the total time with a pH < 4(P = 0.00) ,when upright(P = 0.007) and supine(P = 0.00) . The NERD+ cases had more reflux episodes while upright(P = 0.02) and the ERD cases while supine(P = 0.01) . The LES pressure was higher in cases of NERD+(P = 0.03) while the amplitude and duration of their esophageal peristaltic waves tended to be better than in the ERD group(P >0.05) . The NERD+ patients presented more often with atypical symptoms(P = 0.01) . CONCLUSION:The NERD+ patients’ fewer reflux episodes and the fact that they occurred mainly while in the upright position(unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD+ need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond only partially to medical and surgical treatments. AIM: To investigate differences in the physiopathological findings (manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease (NERD) and erosive reflux disease (ERD) found positive at 24 h pH monitoring. METHODS: For a total of 670 patients who underwent 24 h pH monitoring, esophageal manometry and upper endoscopy were retrospectively evaluated, assessing the reflux symptoms, manometric characteristics of the lower esophageal sphincter (LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms For inclusion in the study, patients had to have NERD or ERD and be found positive on pH monitoring (NERD +). Patients with Gastroesophageal reflux disease (GERD) complicated by stenosis, ulcers or Barrett’s esophagus were ruled out. RESULTS: 214 patients were involved in the study, ie 107 cases of NERD + and 107 of ERD. There were no significant gender-or age-related differences between the two groups. The ERD group had more cases of hiatal hernia (P = 0.02) and more acid reflux, both in terms of number of reflux episodes (P = 0.01) and as a percentage of the total time with pH <4 (P = 0.00) , when upright (P = 0.007) and supine (P = 0.00). The NERD + cases had more reflux episodes while upright (P = 0.02) and the ERD cases while supine (P = 0.01) NERD + (P = 0.03) while the amplitude and duration of their esophageal peristaltic waves tended to be better than in the ERD group (P> 0.05). The NERD + patients presented more often with atypical symptoms (P = 0.01). CONCLUSION: The NERD + patients’ fewer reflux episodes and the fact that they occurred mainly in the upright position (unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD + need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond only partially to medical and surgical treatments.
其他文献
目的了解北京某社区吸毒人员对艾滋病知识及危险行为的知晓情况,为制定吸毒人群预防控制艾滋病的策略提供科学依据。方法采用统一的调查问卷对北京市某社区126例吸毒人员进行
阅读在语文考试中一直占有很大的比重,长期以来广大一线语文教师致力于语文阅读教学的研究,也取得了很大的成绩,但是在高中语文阅读教学中“学困生”仍然广泛的存在,如何帮助
目的探讨白血病患者异基因造血干细胞移植(Allo-HSCT)术后巨细胞病毒(CMV)IgM抗体滴度的动态变化与CMV感染进展的关系。方法采用单克隆抗体免疫荧光测定法和微粒子酶免分析法
AIM: To identify pancreatographic findings that facilitate differentiating between autoimmune pancreatitis (AIP) and pancreatic cancer (PC) on endoscopic retrog
摘 要:笔者在分析当前中国农村学校体育现状的基础上,提出了相应的建议:运用乡土教材,开展特色体育活动激发学生锻炼兴趣;依据当地环境,在教学中动手制作体育器械,让学生身心愉悦;领导重视,培训教师,留住教师;保证活动时间。  关键词:农村学校;体育工作;建议  目前,由于农村学校数量多,摊子大,经济投入有限,再加上思想观念及社会氛围等因素的制约,造成农村中小学体育工作的发展远远落后于城市中小学。  一
Inflammatory bowel diseases are an ideal indication for the laparoscopic surgical approach as they are basically benign diseases not requiring lymphadenectomy a
网络助学是自学考试社会助学的一种重要形式。随着时代的发展,传统的高等教育自学考试助学模式已经无法满足信息时代的需求,网络助学的出现契合了信息时代的发展,在高等教育
Voltage-gated sodium channels (VGSCs) play a fundamental role in controlling cellular excitability,and their abnormal activity is related to several pathologica
AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular
Nitric oxide(NO),a multifunctional endogenous gas molecule,is metabolized from L-arginine by enzymatic reaction in the presence of nitric oxide synthase.NO,an i