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目的探讨术前新辅助化疗对巨块型宫颈癌的近期疗效。方法选择2001年12月至2004年12月华中科技大学同济医学院附属协和医院初治的经病理确诊的68例ⅠB2～ⅡB期巨块型宫颈癌,采用PVB方案化疗2个疗程后手术,观察近期的疗效。结果临床近期有效率达75%,手术切除率达100%。术前新辅助化疗可提高手术切除率和症状改善率,化疗后肿瘤直径较化疗前有不同程度的缩小,差异有显著意义(P<0.05)。所有手术患者均能顺利切除病灶并达到切缘距离病灶1cm以上。结论术前新辅助化疗可提高宫颈癌的近期疗效,成为治疗该病的一种新手段,具有重要的临床意义。
Objective To investigate the short-term curative effect of preoperative neoadjuvant chemotherapy on massive cervical cancer. Methods From December 2001 to December 2004, Huazhong University of Science and Technology Tongji Medical College Affiliated Union Hospital, the newly diagnosed 68 cases of Ⅰ B2 ~ Ⅱ B period of massive cervical cancer, the use of PVB regimen after 2 courses of surgery, observation The recent effect. Results The clinical effective rate of 75%, surgical resection rate of 100%. Neoadjuvant chemotherapy before surgery can improve the rate of surgical resection and the rate of improvement. The diameter of the tumor after chemotherapy is reduced to some extent compared with that before chemotherapy, with significant difference (P <0.05). All surgical patients were able to successfully remove the lesion and reach the edge more than 1cm away from the lesion. Conclusion Preoperative neoadjuvant chemotherapy can improve the short-term effect of cervical cancer and become a new treatment for the disease, which has important clinical significance.