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目的 研究PCNA与BCL - 2的表达在大肠癌预后评估中的意义。方法 用sABC免疫组化法分析 3年随访期间大肠癌患者肠标本的PCNA与BCL - 2的表达。结果 PCNA在正常大肠黏膜中不表达而在大肠癌中呈阳性表达 ,PCNA与肿瘤的复发、患者的死亡时间、肿瘤分期和淋巴道转移呈正相关 (P <0 .0 5 ) ,而与患者的年龄、性别和肿瘤部位呈负相关。BCL - 2仅与肿瘤分期高度相关 (P <0 .0 5 ) ,与复发时间、死亡时间、年龄、性别和肿瘤部位无关 (P >0 .0 5 )。结论 分析PCNA与BCL - 2的表达对大肠癌的临床治疗和预后评估具有重要意义
Objective To study the significance of PCNA and BCL - 2 expression in the prognosis of colorectal cancer. Methods The expression of PCNA and BCL - 2 in intestinal samples of patients with colorectal cancer during 3 years follow - up were analyzed by sABC immunohistochemistry. Results PCNA was not expressed in normal colorectal mucosa but was positively expressed in colorectal cancer. There was a positive correlation between PCNA and tumor recurrence, patient’s death time, tumor stage and lymphatic metastasis (P <0.05) Age, sex and tumor sites were negatively correlated. BCL - 2 was highly correlated with tumor stage (P <0.05), but not with recurrence time, death time, age, sex and tumor location (P> 0.05). Conclusions It is of great significance to analyze the expression of PCNA and BCL - 2 in clinical treatment and prognosis of colorectal cancer