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盐水渗透脆性试验是目前检测红细胞脆性的常规试验。但该法操作冗繁费时,且灵敏度较低,不利于临床常规开展。1974年Gottfried等发现红细胞在一定浓度的甘油溶液中的溶解速率与红细胞膜脆性有关,建立了甘油溶血试验。
Saline infiltration fragility test is the routine test to detect the fragility of red blood cells. However, the method is redundant and time-consuming operation, and the sensitivity is low, is not conducive to clinical routine. In 1974, Gottfried et al. Found that the dissolution rate of erythrocytes in a certain concentration of glycerol solution was related to the erythrocyte membrane fragility, and a glycerol hemolysis test was established.