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目的：了解恶性网织细胞增生症（MMH）的病理形态学改变，从免疫表型的研究角度进一步阐明MMH中异型淋巴细胞（ALC）的来源属性，探讨MMH与恶性淋巴瘤的关系。方法：对确诊的39例MMH病理组织切片常规HE染色，光镜下观察病理形态改变；同时行免疫组织化学染色（SP法）。结果：①MMH的病理为凝固性坏死伴混合炎性细胞浸润，具有亲上皮性浸润、围绕血管中心分布和破坏血管等特征。②39例MMH中28例（71．8％）表达T细胞免疫表型，同时表达CD3和CD57的13例（33．3％）。结论：ALC主要是来自异形T细胞的增生和浸润。ALC除表达CD3免疫表型外，还表达CD57的免疫标记。MMH是一种粘膜相关淋巴组织来源的周围T／NK细胞淋巴瘤。
Objective: To understand the pathomorphological changes of malignant reticulocyte hyperplasia (MMH), to further elucidate the origin of atypical lymphocytes (ALC) in MMH from the perspective of immunophenotyping, and to explore the relationship between MMH and malignant lymphoma. METHODS: Twenty-nine cases of confirmed MMH histopathological sections were stained with HE, light pathological changes were observed, and immunohistochemical staining (SP method) was performed. RESULTS: 1 The pathology of MMH was coagulative necrosis with mixed inflammatory cell infiltration, with pro-epithelial infiltrate, distribution around blood vessels, and destruction of blood vessels. Of the 239 cases of MMH, 28 (71.8%) expressed T-cell immunophenotype, while 13 cases (33.3%) expressed both CD3 and CD57. Conclusion: ALC is mainly derived from the proliferation and infiltration of abnormal T cells. In addition to the CD3 immunophenotype, ALC also expresses CD57 immunolabeling. MMH is a peripheral T/NK cell lymphoma derived from mucosa-associated lymphoid tissue.