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采用生物分析法检测妇女孕３８周和分娩后１ｈ血浆血小板激活因子（ＰＡＦ）的水平，以了解分娩前后母体ＰＡＦ水平的变化及其与妊娠高血压综合征（妊高征）的潜在关系。结果：正常妊娠组孕３８周的ＰＡＦ活性为（２５．００±５．６５）μｇ／Ｌ，显著高于轻中度妊高征组［（１４．７４±４．５６）μｇ／Ｌ］和重度好高征组［（１１．４５±６．０８）μｇ／Ｌ］（均为Ｐ＜０．０５）。三组孕妇分娩后１ｈ的ＰＡＦ活性分别为（３３．９０±４．１２）、（３２．２８±５．９３）和（３５．９３±１０．８３）μｇ／Ｌ，均显著高于同组孕３８周的水平（均为Ｐ＜０．０５）。结果提示，血小板激活因子可能参与好高征的发病机制，而胎盘在血小板激活因子的代谢调节中具有重要的地位。
Bioanalytical method was used to detect the levels of PAF in pregnant women for 38 weeks and 1 hour after delivery to find out the potential changes of maternal PAF levels before and after delivery and its potential relationship with pregnancy induced hypertension syndrome (PIH). Results: The PAF activity in normal pregnancy group was (25.00 ± 5.65) μg / L at 38 weeks pregnant, which was significantly higher than that in mild to moderate pregnancy induced hypertension group (14.74 ± 4.56 μg / L) and Severe hyperglycemia group [(11.45 ± 6.08) μg / L] (all P <0.05). The PAF activities of the three groups at 1 hour after delivery were (33.90 ± 4.12), (32.28 ± 5.93) and (35.93 ± 10.83) μg / L, respectively, which were significantly higher than those in the same group 38 weeks pregnant (all P <0.05). The results suggest that platelet activating factor may be involved in the pathogenesis of hyperglycemia, and the placenta plays an important role in the regulation of platelet activating factor metabolism.