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目的研究膨胀性气体Ｃ３Ｆ８对玻璃体出血机化有何影响。方法新西兰大白兔８只，全麻下双眼抽取前房水０．１ｍｌ，平坦部注射自体抗凝血０．１ｍｌ。４８小时后，抽双眼前房水０．１ｍｌ，随机在各兔右眼或左眼注Ｃ３Ｆ８气体０．３ｍｌ于玻璃体腔内。另眼注０．１ｍｌ的生理盐水作对照。术后散瞳查眼底及玻璃体。观察玻璃体出血和气体吸收情况。结果注气眼与对照眼玻璃体出血的消退在时间上有显著性差异，Ｐ＜０．０５。对照眼最终有３只眼发生牵引性视网膜脱离。注气眼出血完全吸收后，均未发生视网膜脱离。未发生视网膜脱离眼，两组ＥＲＧ均正常，无明显差异。而有网脱的眼，ＥＲＧ明显下降。结论Ｃ３Ｆ８气体在玻璃体手术和黄斑裂孔视网膜脱离的患者中得到成熟的运用，无明显副作用。动物实验亦说明Ｃ３Ｆ８气体在玻璃体出血机化患者的应用是可行的。早期破坏玻璃体支架结构，有助于预防出血引起的牵引性视网膜脱离。
Objective To study the effect of expansive gas C3F8 on vitreous hemorrhage. Methods Eight New Zealand white rabbits were anesthetized with 0.1 ml anterior chamber water extracted from both eyes and 0.1 ml autogenous anticoagulant injected into the flat part. Forty-eight hours later, both eyes were anesthetized with 0.1 ml aqueous humor and randomly injected with 0.3 ml of C3F8 gas in the right or left eye of each rabbit in the vitreous chamber. Another eye note 0.1ml saline as a control. Mydriasis after fundus examination and vitreous. Vitreous hemorrhage and gas absorption were observed. Results There was a significant difference in time with the regression of vitreous hemorrhage between insufflation and control eyes, P <0.05. The control eye eventually had traction retinal detachment in 3 eyes. Injection of eye bleed completely absorbed, no retinal detachment occurred. Retinal detachment did not occur in both eyes ERG were normal, no significant difference. The net off the eyes, ERG decreased significantly. Conclusions C3F8 gas has been used successfully in patients with vitreous surgery and macular hole retinal detachment without obvious side effects. Animal experiments also illustrate the C3F8 gas in patients with vitreous hemorrhage is feasible. Early destruction of the vitreous scaffold structure, helps to prevent bleeding induced traction retinal detachment.