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目的探讨丁苯酞对急性脑梗塞患者的疗效及其作用机制。方法选取急性脑梗塞患者90例,分为A组和B组各45例,A组给予一般常规治疗,B组在上述基础上给予丁苯酞治疗,比较两组临床总有效率及血清同型半胱氨酸(Hcy)和C反应蛋白(CRP)水平。结果 B组总有效率显著高于A组,差异具有统计学意义。两组患者治疗后血清Hcy和CRP水平较治疗前均显著降低,但B组治疗后降低更明显(P<0.01)。结论丁苯酞可通过降低血清Hcy和CRP水平,降低炎症反应水平,改善急性脑梗塞患者病情。
Objective To investigate the efficacy and mechanism of butylphthalide in patients with acute cerebral infarction. Methods 90 patients with acute cerebral infarction were selected and divided into group A and group B, 45 cases each. Group A received conventional treatment. Group B received butylphthalide on the basis of the above. The total effective rate and serum homology Cystine (Hcy) and C-reactive protein (CRP) levels. Results The total effective rate in group B was significantly higher than that in group A, the difference was statistically significant. After treatment, the levels of Hcy and CRP in both groups were significantly lower than those before treatment, but the levels of Hcy and CRP in group B were significantly lower after treatment (P <0.01). Conclusion Butylphthalide can reduce the level of serum Hcy and CRP, reduce the level of inflammation and improve the patients with acute cerebral infarction.