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目的:了解武汉地区妇女宫颈感染人乳头瘤病毒(human papillom avirus,HPV)基因型的分布情况。方法:取妇女宫颈的脱落细胞,利用基因芯片技术检测18种高危型HPV和5种低危型HPV。结果:总共检测606例,HPV总共感染391例,感染率64.5%。高危型HPV感染274例,感染率45.2%;高危型HPV感染率排在前5位的依次是HPV16(24.6%)、HPV18(10.4%)、HPV58(5.3%)、HPV33(2.8%)、HPV56(1.5%)。仅感染低危型HPV为117例,感染率为19.3%。单一基因型感染332例,占感染人数的84.9%;两重感染53例,占感染人数的13.6%;三重感染6例,占感染人数的1.5%。结论:武汉地区妇女宫颈HPV感染率较高,主要为单一基因型感染;高危型HPV主要是HPV16和18,其次是HPV58、33、56。
Objective: To understand the distribution of cervical papillomavirus (HPV) genotypes in Wuhan women. Methods: The exfoliated cells of the cervix were taken from women. 18 high-risk HPVs and 5 low-risk HPVs were detected by gene chip technique. Results: A total of 606 cases were detected, with a total of 391 HPV infections, the infection rate was 64.5%. 274 cases of high-risk HPV infection, the infection rate was 45.2%; high-risk HPV infection in the top five were HPV16 (24.6%), HPV18 (10.4%), HPV58 (1.5%). Only 117 cases of low-risk HPV infection, the infection rate was 19.3%. A single genotype infection 332 cases, accounting for 84.9% of the number of infections; double infection in 53 cases, accounting for 13.6% of the number of infections; triple infection in 6 cases, accounting for 1.5% of the number of infections. Conclusion: The prevalence of cervical HPV infection is higher in women in Wuhan area, which is mainly single genotype. The high-risk HPV is mainly HPV16 and HPV18, followed by HPV58, 33 and 56.