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目的探讨抑制素B(INH-B)在多囊卵巢综合征(PCOS)患者血清中的变化,分析INH-B在PCOS发病中的可能作用。方法用免疫组化法检测45例多囊卵巢综合征和20例月经正常的育龄期妇女的血清INH-B水平。结果PCOS组血清INH-B水平高于对照组,PCOS非肥胖组血清INH-B水平高于肥胖组,差异有极显著性意义(P<0.01)。PCOS组血清INH-B水平与LH、FSH、T呈正相关,与BMI呈负相关。对照组血清INH-B水平与BMI呈负相关。结论INH-B参与了PCOS患者性激素分泌失调的形成。检测与调节PCOS患者的血清INH-B水平可能有助于指导PCOS的治疗。
Objective To investigate the changes of serum inhibin B (INH-B) in patients with polycystic ovary syndrome (PCOS) and to analyze the possible role of INH-B in the pathogenesis of PCOS. Methods The serum levels of INH-B in 45 cases of polycystic ovary syndrome and 20 cases of normal menstruation women of childbearing age were detected by immunohistochemistry. Results The serum level of INH-B in PCOS group was higher than that in control group. The level of INH-B in PCOS non-obese group was higher than that in obese group, the difference was significant (P <0.01). The level of INH-B in PCOS group was positively correlated with LH, FSH, T and negatively correlated with BMI. The level of INH-B in the control group was negatively correlated with BMI. Conclusion INH-B participates in the formation of sex hormones in patients with PCOS. Detection and regulation of serum INH-B levels in patients with PCOS may help guide the treatment of PCOS.