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目的建立复方血栓通胶囊微生物限度检查方法。方法采用《中国药典》(2010年版)一部微生物限度检查法对复方血栓通胶囊微生物限度检查进行验证。结果复方血栓通胶囊对金黄色葡萄球菌,枯草芽孢杆菌有抑制作用,不适宜采用平皿法检查。因此选择用培养基稀释法消除其抑菌活性。结论本品细菌数检查可用培养基稀释法;霉菌和酵母菌数可用常规法;大肠埃希菌检查可常规法进行检测。
Objective To establish a method for the determination of microbial limit of compound Xueshuantong capsule. Methods The microbial limit test of “Chinese Pharmacopoeia” (2010 edition) was used to verify the limits of the compound Xueshuantong capsule. Results Compound Xueshuantong capsule Staphylococcus aureus, Bacillus subtilis inhibitory effect, not suitable for use plate test. Therefore, choose to use medium dilution method to eliminate its antibacterial activity. Conclusion The bacterial count can be used medium dilution method; the number of molds and yeasts can be routine; Escherichia coli test can routinely test.