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本文通过凝固浴成球法,制备了颅通定/壳多糖药物缓释小球。考察了颅通定/壳多糖配比、交联剂、壳多糖分子量等因素对制剂药物含量和溶出速度的影响。结果表明,含药量56.7%的缓释小球,在模拟胃、肠液中,T_(50)分别可达40min和180min;全部溶出时间可达9h和12h。
In this paper, by coagulation bath into the ball method, craniofacial fixed / chitosan drug sustained release pellets. The effects of craniocervical fixed-to-chitosan ratio, crosslinking agent, chitosan molecular weight and other factors on drug content and dissolution rate were investigated. The results showed that T_ (50) in gastric and intestine fluid with contents of 56.7% could reach 40min and 180min, respectively. The total dissolution time could reach 9h and 12h.