人们普遍认为雌激素(E)可增加乳腺癌的发病率以及加速已发生的乳腺癌的进展。并证实E可加速肿瘤细胞的增殖,影响原癌基因和生长因子的表达。尽管较高的内、外源E水平可能与乳腺癌发生率升高有关,但E对乳腺癌病程的进展有不利影响的证据非常少见。实验室证据显示E对乳腺癌的发展和预后可能有有利的影响。其中之一是E受体阳性的乳腺癌细胞通常恶性度较低且分化程度较高。 It is generally accepted that estrogen (E) increases the incidence of breast cancer and accelerates the progression of breast cancer that has taken place. And confirmed that E can accelerate the proliferation of tumor cells, affecting the expression of proto-oncogene and growth factor. Although higher levels of exogenous E may be associated with an increased incidence of breast cancer, there is very little evidence that E has an adverse effect on the progression of breast cancer. Laboratory evidence suggests that E may have beneficial effects on the development and prognosis of breast cancer. One of them is that E receptor-positive breast cancer cells usually have a lower degree of malignancy and a higher degree of differentiation.